Acupuncture is one of the safest forms of medical treatment for animals when administered by a properly trained veterinarian. Side effects of acupuncture are rare, but they do exist. An animal’s condition may seem worse for up to 48 hours after a treatment. Other animals may become sleepy or lethargic for 24 hours after acupuncture. These effects are an indication that some physiological changes are developing, and they are most often followed by an improvement in the animal’s condition.